Karen E. Wetterhahn: search on Z-Library

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1

Reduction of Chromium(VI) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitro

Stearns, Diane M., Kennedy, Laura J., Courtney, Kevin D., Giangrande, Paloma H., Phieffer, Laura S., Wetterhahn, Karen E.

Journal:

Year:

1995

Language:

english

File:

PDF, 1.80 MB

english, 1995

2

Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage

Aiyar, Jayshree, Berkovits, Holly J., Floyd, Robert A., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1990

Language:

english

File:

PDF, 1.18 MB

english, 1990

3

Differential Effects of Chromium(VI) on Constitutive and Inducible Gene Expression in Chick Embryo Liver In Vivo and Correlation With Chromium(VI)-Induced DNA Damage

Joshua W. Hamilton, Karen E. Wetterhahn

Journal:

Molecular Carcinogenesis

Year:

1989

Language:

english

File:

PDF, 1.22 MB

english, 1989

4

Reaction of Chromium(VI) with Ascorbate Produces Chromium(V), Chromium(IV), and Carbon-Based Radicals

Stearns, Diane M., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1994

Language:

english

File:

PDF, 1.53 MB

english, 1994

5

Reduction of carcinogenic chromium(VI) by dehydroascorbate and its decomposition products.

Diane M. Stearns, Karen E. Wetterhahn

Journal:

Journal of Inorganic Biochemistry

Year:

1993

Language:

english

File:

PDF, 77 KB

english, 1993

6

Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes

Joshua W. Hamilton, William J. Bement, Peter R. Sinclair, Jacqueline F. Sinclair, Joy A. Alcedo, Karen E. Wetterhahn

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 1.23 MB

english, 1992

7

Identification of the Oxidized Products Formed upon Reaction of Chromium(V) with Thymidine Nucleotides

Sugden, Kent D., Wetterhahn, Karen E.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 365 KB

english, 1996

8

Chromium(VI) Toxicity: Uptake, Reduction, and DNA Damage

Standeven, Andrew, Wetterhahn, Karen

Journal:

International Journal of Toxicology

Year:

1989

Language:

english

File:

PDF, 598 KB

english, 1989

9

Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo

Hamilton, Joshua W., Wetterhahn, Karen E.

Journal:

Year:

1986

Language:

english

File:

PDF, 433 KB

english, 1986

10

Chromium bound to DNA alters cleavage by restriction endonucleases

Borges, Kim M., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1991

Language:

english

File:

PDF, 1.60 MB

english, 1991

11

Solubilization of the carcinogen nickel subsulfide and its interaction with DNA and protein

Lee, Jeffrey E., Ciccarelli, Richard B., Jennette, Karen Wetterhahn

Journal:

Year:

1982

Language:

english

File:

PDF, 1.00 MB

english, 1982

12

Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr—DNA binding in liver and 8-0X0-2’-deoxyguanosine in red blood cells

Misra, Manoj, Alcedo, Joy A., Wetterhahn, Karen E.

Journal:

Year:

1994

Language:

english

File:

PDF, 740 KB

english, 1994

13

Reaction of Chromium(VI) with Glutathione or with Hydrogen Peroxide: Identification of Reactive Intermediates and Their Role in Chromium(VI)-Induced DNA Damage

Jayshree Aiyar, Holly J. Berkovits, Robert A. Floyd and Karen E. Wetterhahn

Journal:

Environmental Health Perspectives

Year:

1991

Language:

english

File:

PDF, 515 KB

english, 1991

14

Inhibition of NF-κB Binding to DNA by Chromium, Cadmium, Mercury, Zinc, and Arsenitein Vitro:Evidence of a Thiol Mechanism

Jennifer A. Shumilla, Karen E. Wetterhahn, Aaron Barchowsky

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 172 KB

english, 1998

15

Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription

Joshua W. Hamilton, William J. Bement, Peter R. Sinclair, Jacqueline F. Sinclair, Joy A. Alcedo, Karen E. Wetterhahn

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 835 KB

english, 1991

16

EPR Evidence for Chromium(V) Binding to Phosphate and Pyrophosphate: Implications for Chromium(V)−DNA Interactions

Sugden, Kent D., Wetterhahn, Karen E.

Journal:

Inorganic Chemistry

Year:

1996

Language:

english

File:

PDF, 112 KB

english, 1996

17

Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation

Wilker, Jonathan J., Wetterhahn, Karen E., Lippard, Stephen J.

Journal:

Inorganic Chemistry

Year:

1997

Language:

english

File:

PDF, 160 KB

english, 1997

18

Differential binding of chromium(VI) and chromium(III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA

Hneihen, Azzam S., Standeven, Andrew M., Wetterhahn, Karen E.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.06 MB

english, 1993

19

Arsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cells

Aaron Barchowsky, Edward J. Dudek, Melinda D. Treadwell, Karen E. Wetterhahn

Journal:

Free Radical Biology and Medicine

Year:

1996

Language:

english

File:

PDF, 1.03 MB

english, 1996

20

The genotoxic carcinogen chromium(VI) alters the metal-inducible expression but not the basal expression of the metailothionein gene in vivo

Alcedo, Joy A., Misra, Manoj, Hamilton, Joshua W., Wetterhahn, Karen E.

Journal:

Year:

1994

Language:

english

File:

PDF, 457 KB

english, 1994

21

The interaction of chromium with nucleic acids

Michael J. Tsapakos, Karen E. Wetterhahn

Journal:

Chemico-Biological Interactions

Year:

1983

Language:

english

File:

PDF, 1.04 MB

english, 1983

22

Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved?

Aiyar, Jayshree, De Flora, Silvio, Wetterhahn, Karen E.

Journal:

Year:

1992

Language:

english

File:

PDF, 4.48 MB

english, 1992

23

Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?

Standeven, Andrew M., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1991

Language:

english

File:

PDF, 1.49 MB

english, 1991

24

Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, and mediates chromium–DNA binding in vitro

Standeven, Andrew M., Wetterhahn, Karen E., Kato, Ryuichi

Journal:

Year:

1992

Language:

english

File:

PDF, 4.37 MB

english, 1992

25

Chromium cross-links glutathione and cysteine to DNA

Borges, Kim M., Wetterhahn, Karen E.

Journal:

Year:

1989

Language:

english

File:

PDF, 420 KB

english, 1989

26

Effect of chromium(III) on poly(dG-dC) conformation

Norman A. Floro, Karen E. Wetterhahn

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 402 KB

english, 1984

27

Interlaboratory validation of a new assay for DNA-protein crosslinks

Max Costa, Anatoly Zhitkovich, Michael Gargas, Dennis Paustenbach, Brent Finley, Jim Kuykendall, Ruth Billings, Timothy J. Carlson, Karen Wetterhahn, Jian Xu, Steven Patierno, Matthew Bogdanffy

Journal:

Mutation Research/Genetic Toxicology

Year:

1996

Language:

english

File:

PDF, 641 KB

english, 1996

28

Role of chromium(V), glutathione thiyl radical and hydroxyl radical intermediates in Chromium(VI)‐induced DNA Damage

Aiyar, Jayshree, Borges, Kim M., Floyd, Robert A., Wetterhahn, Karen E.

Journal:

Toxicological & Environmental Chemistry

Year:

1989

Language:

english

File:

PDF, 747 KB

english, 1989

29

Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis

Wise, John Pierce, Stearns, Diane M., Wetterhahn, Karen E., Patierno, Steven R.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.42 MB

english, 1994

30

Possible Role of Glutathione in Chromium(VI) Metabolism and Toxicity in Rats

Andrew M. Standeven, Karen E. Wetterhahn

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1991

Language:

english

File:

PDF, 873 KB

english, 1991

31

Chromium(VI) forms a thiolate complex with glutathione

Brauer, Samuel L., Wetterhahn, Karen E.

Journal:

Journal of the American Chemical Society

Year:

1991

Language:

english

File:

PDF, 888 KB

english, 1991

32

Activation of chromium(VI) by thiols results in chromium(V) formation, chromium binding to DNA and altered DNA conformation

Borges, Kim M., Boswell, John S., Liebross, Robert H., Wetterhahn, Karen E.

Journal:

Year:

1991

Language:

english

File:

PDF, 6.00 MB

english, 1991

33

Mechanism of chromium(VI) carcinogenesis: Reactive intermediates and interaction with DNA

KarenE. Wetterhahn

Journal:

Journal of Inorganic Biochemistry

Year:

1989

Language:

english

File:

PDF, 57 KB

english, 1989

34

In vivo formation of chromium(V) in chick embryo liver and red blood cells

Liebross, Robert H., Wetterhahn, Karen E.

Journal:

Year:

1992

Language:

english

File:

PDF, 2.90 MB

english, 1992

35

Tissue-specific changes in glutathione and cysteine after buthionine sulfoximine treatment of rats and the potential for artifacts in thiol levels resulting from tissue preparation

Andrew M. Standeven, Karen E. Wetterhahn

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.38 MB

english, 1991

36

Direct and Hydrogen Peroxide-Induced Chromium(V) Oxidation of Deoxyribose in Single-Stranded and Double-Stranded Calf Thymus DNA

Sugden, Kent D., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 270 KB

english, 1997

37

Mitochondrial reduction of the carcinogen chromate: formation of chromium(V)

Rossi, Susan C., Gorman, Nadia, Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1988

Language:

english

File:

PDF, 937 KB

english, 1988

38

In vitro interaction of 63-nickel(II) with chromatin and DNA from rat kidney and liver nuclei

Richard B. Ciccarelli, Karen E. Wetterhahn

Journal:

Chemico-Biological Interactions

Year:

1985

Language:

english

File:

PDF, 844 KB

english, 1985

39

Reaction of Chromium(V) with the EPR Spin Traps 5,5-Dimethylpyrroline N -Oxide and Phenyl- N - tert -butylnitrone Resulting in Direct Oxidation

Sugden, Kent D., Wetterhahn, Karen E.

Journal:

Inorganic Chemistry

Year:

1996

Language:

english

File:

PDF, 342 KB

english, 1996

40

Ascorbate is the principal reductant of chromium(VI) in rat liver and kidney ultrafiltrates

Standeven, Andrew M., Wetterhahn, Karen E.

Journal:

Year:

1991

Language:

english

File:

PDF, 526 KB

english, 1991

41

Chromium(VI) Forms Thiolate Complexes with γ-Glutamylcysteine, N -Acetylcysteine, Cysteine, and the Methyl Ester of N -Acetylcysteine †

Brauer, Samuel L., Hneihen, Azzam S., McBride, John S., Wetterhahn, Karen E.

Journal:

Inorganic Chemistry

Year:

1996

Language:

english

File:

PDF, 431 KB

english, 1996

42

Supplement 3: Molecular Mechanisms of Metal Toxicity and Carcinogenicity || Chromium(VI) Reduction by Ascorbate: Role of Reactive Intermediates in DNA Damage In Vitro

Diane M. Stearns, Kevin D. Courtney, Paloma H. Giangrande, Laura S. Phieffer and Karen E. Wetterhahn

Journal:

Environmental Health Perspectives

Year:

1994

Language:

english

File:

PDF, 1006 KB

english, 1994

43

In vivo formation of chromium(V) in chick embryo red blood cells

Liebross, Robert H., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1990

Language:

english

File:

PDF, 395 KB

english, 1990

44

Mechanism of chromium(VI) carcinogenesis

Karen E. Wetterhahn, Joshua W. Hamilton, Jayshree Aiyar, Kim M. Borges, Robert Floyd

Journal:

Biological Trace Element Research

Year:

1989

Language:

english

File:

PDF, 478 KB

english, 1989

45

Molecular basis of hexavalent chromium carcinogenicity: Effect on gene expression

Karen E. Wetterhahn, Joshua W. Hamilton

Journal:

Science of The Total Environment

Year:

1989

Language:

english

File:

PDF, 1.02 MB

english, 1989

46

Intermediates Produced in the Reaction of Chromium(VI) with Dehydroascorbate Cause Single-Strand Breaks in Plasmid DNA

Stearns, Diane M., Wetterhahn, Karen E.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 305 KB

english, 1997

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